Molecular Parasitology Laboratory, the Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD 4029, Australia.
Trends Parasitol. 2012 Dec;28(12):572-9. doi: 10.1016/j.pt.2012.09.005. Epub 2012 Oct 22.
Pathology in schistosomiasis occurs as a result of eggs deposited in the liver by the schistosome parasite. A granulomatous reaction occurs, resulting in portal hypertension and hepatic fibrosis. Resident non-parenchymal cells within the liver take part in this process, including hepatic stellate cells, which are responsible for collagen production, and Kupffer cells, the liver macrophages involved in both host protection and in pathology. Other cells such as liver sinusoidal endothelial cells or portal fibroblasts may also be involved in this process. This review discusses the possible role of these resident liver cells in the pathology associated with schistosomiasis and provides information which may assist our understanding of the mechanisms associated with chronic liver disease in general.
血吸虫病的病理学是由血吸虫寄生虫在肝脏中沉积的卵引起的。发生了肉芽肿反应，导致门脉高压和肝纤维化。肝脏中的常驻非实质细胞参与了这个过程，包括负责胶原蛋白产生的肝星状细胞和库普弗细胞，库普弗细胞参与宿主保护和病理学。其他细胞，如肝窦内皮细胞或门脉成纤维细胞，也可能参与这个过程。这篇综述讨论了这些常驻肝细胞在与血吸虫病相关的病理学中的可能作用，并提供了可能有助于我们理解一般慢性肝病相关机制的信息。
