Department of Biotechnology, School of Biotechnology and Graduate School of Biochemistry, Yeungnam University, Gyeongsan, South Korea.
Apoptosis. 2012 Dec;17(12):1247-57. doi: 10.1007/s10495-012-0775-5.
The PYRIN domain (PYD) is a well known protein interaction module and a prime mediator of the protein interactions necessary for apoptosis, inflammation and innate immune signaling pathway. Because PYD-mediated apoptosis, inflammation and innate immune processes are associated with many human diseases, studies in these areas are of great biological importance. Intensive biochemical and structural studies of PYD have been conducted in the past decade to elucidate PYD-mediated signaling events, and evaluations of the molecular structure of PYDs have shown the underlying molecular basis for the assembly of PYD-mediated complexes and for the regulation of inflammation and innate immunity. This review summarizes the structure and function of various PYDs and proposes a PYD:PYD interaction for assembly of the complexes involved in those signaling pathways.
PYRIN 结构域（PYD）是一种众所周知的蛋白质相互作用模块，是细胞凋亡、炎症和先天免疫信号通路所必需的蛋白质相互作用的主要介质。由于 PYD 介导的细胞凋亡、炎症和先天免疫过程与许多人类疾病有关，因此这些领域的研究具有重要的生物学意义。在过去的十年中，人们对 PYD 进行了深入的生化和结构研究，以阐明 PYD 介导的信号事件，对 PYDs 分子结构的评估揭示了 PYD 介导的复合物组装的潜在分子基础，以及炎症和先天免疫的调节机制。本综述总结了各种 PYDs 的结构和功能，并提出了 PYD:PYD 相互作用，以组装参与这些信号通路的复合物。
