INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse Cedex, France.
ANSES, Laboratoire d'Etudes et de Recherches Caprines, BP 3081, 79012 Niort Cedex, France.
J Gen Virol. 2013 Jan;94(Pt 1):241-245. doi: 10.1099/vir.0.047225-0. Epub 2012 Oct 24.
The PrP gene polymorphisms at codons 142 (I/M), 154 (R/H), 211 (R/Q), 222 (Q/K) and 240 (S/P) and their association with susceptibility to classical scrapie infection were investigated in five French goat herds displaying a high disease prevalence (>10%). On the basis of PrP(Sc) detection in the central nervous system and in various lymphoid tissues, 301 of 1343 goats were found to be scrapie infected. The statistical analyses indicated that while P(240) mutation had no direct impact on scrapie infection risk, the H(154), Q(211) and K(222) mutations were associated with high resistance to scrapie. The M(142) mutated allele was associated with a limited protection level against the disease. These results further reinforce the view that, like in sheep, the control and eradication of classical scrapie through the selection of certain PrP alleles could be envisaged in commercial goat population.
研究了在五个法国山羊群中，与经典瘙痒感染易感性相关的 PrP 基因密码子 142（I/M）、154（R/H）、211（R/Q）、222（Q/K）和 240（S/P）的多态性。这五个山羊群的疾病流行率（>10%）较高。根据中枢神经系统和各种淋巴组织中 PrP(Sc)的检测，在 1343 只山羊中发现 301 只患有瘙痒感染。统计分析表明，虽然 P(240)突变对瘙痒感染风险没有直接影响，但 H(154)、Q(211)和 K(222)突变与抗瘙痒感染的高抗性有关。M(142)突变等位基因与对该疾病的有限保护水平有关。这些结果进一步证实了这样一种观点，即在绵羊中，通过选择某些 PrP 等位基因来控制和根除经典瘙痒感染，可以在商业山羊种群中进行。
