实验室培养的螺旋藻的体外抗菌活性。
In vitro antibacterial activity of laboratory grown culture of Spirulina platensis.
机构信息
Department of Botany and Microbiology, Gurukul Kangri University, Hardwar, 249 404 Uttarakhand, India.
出版信息
Indian J Microbiol. 2008 Sep;48(3):348-52. doi: 10.1007/s12088-008-0043-0. Epub 2009 Mar 25.
Abstract
The hexane, ethyl acetate, dichloromethane, methanol extracts and spent media (extracellular substances) were tested in vitro for their antibacterial activity for which one Gram-positive bacterium (Staphylococcus aureus) and four Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Klebsiella pneumoniae) were used as test organisms. The methanol extract showed more potent activity than other organic extracts, spent medium of the culture exhibited little activity against E. coli only. No inhibitory effect was found against Klebsiella pneumoniae.The broth microdilution assay gave minimum inhibitory concentrations (MIC) values ranging from 1 to 512 μg/ml. The MIC of methanol extract against S. aureus and E. coli were 128 μg/ml and 256 μg/ml, respectively.
摘要
该实验对正烷、乙酸乙酯、二氯甲烷、甲醇提取物和用过的培养基（细胞外物质）进行了体外抗菌活性测试，其中使用了一株革兰氏阳性菌（金黄色葡萄球菌）和四株革兰氏阴性菌（大肠杆菌、铜绿假单胞菌、伤寒沙门氏菌和肺炎克雷伯菌）作为测试生物。甲醇提取物的活性强于其他有机提取物，而培养物的用过的培养基仅对大肠杆菌表现出微弱的活性。对肺炎克雷伯菌没有发现抑制作用。肉汤微量稀释法测定的最小抑菌浓度（MIC）值范围为 1 至 512 μg/ml。甲醇提取物对金黄色葡萄球菌和大肠杆菌的 MIC 值分别为 128 μg/ml 和 256 μg/ml。
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