Department of Biological Sciences, Nasarawa State University Keffi, Keffi, Nigeria.
Indian J Microbiol. 2009 Sep;49(3):233-6. doi: 10.1007/s12088-009-0035-8. Epub 2009 Jun 13.
Coinfection with HIV and Mycobacterium tuberculosis is known to be a lethal combination especially with its attendant mortality and morbidity. The need to have a baseline data in an environment like Keffi with a HIV/AIDS prevalence of 38.6% necessitated this study. Three hundred and ninety people living with HIV/AIDS (PLWHA) were screened for pulmonary tuberculosis. Results of this study showed 16.7% prevalence of coinfection in the population. Gender-related prevalence of coinfection was 19.4% and 14.4% among males and females respectively (P>0.05). Age-related prevalence of coinfection was least among respondents of age below 20 years (13.3%) and highest among those of age above 40 years (20.2%) (P>0.05). Even though statistically insignificant by both parameters, these findings are of public health significance. There is therefore an urgent need for immediate intervention to allow for early TB diagnosis, institution of anti-TB treatment and provision of prophylaxis against TB among TB-negative PLWHA.
已知 HIV 和结核分枝杆菌的合并感染是致命的，尤其是伴随着其死亡率和发病率。在像凯菲这样 HIV/AIDS 患病率为 38.6%的环境中，需要有基线数据，这促使了这项研究的开展。对 390 名 HIV/AIDS 患者进行了肺结核筛查。研究结果显示，该人群中合并感染的患病率为 16.7%。合并感染的性别相关患病率分别为男性 19.4%和女性 14.4%（P>0.05）。年龄相关的合并感染患病率在年龄低于 20 岁的受访者中最低（13.3%），在年龄大于 40 岁的受访者中最高（20.2%）（P>0.05）。尽管这两个参数的统计学意义不显著，但这些发现具有公共卫生意义。因此，迫切需要立即进行干预，以便对 TB 阴性的 PLWHA 进行早期 TB 诊断、抗 TB 治疗和 TB 预防。
