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肥胖症中多形核白细胞的唾液酸和唾液酸酶活性

Polymorphonuclear leukocytic sialic acid and sialidase activity in obesity.

作者信息

Das R K, Muddeshwar M G

机构信息

Department of Biochemistry, Government Medical College Nagpur, 440003 Nagpur, India.

出版信息

Indian J Clin Biochem. 1997 Jul;12(2):114-8. doi: 10.1007/BF02873673.

Abstract

The level of sialic acid in the obese polymorphonuclear leukocytes (PMNL) was found to be significantly reduced as compared to normal. Activity of sialic acid degrading enzyme, sialidase, was found to be increased in the obese state. Restoration in both sialic acid content and sialidase activity was also evidenced in the PMNL of treated obese patients.

摘要

与正常情况相比,肥胖者的多形核白细胞(PMNL)中的唾液酸水平显著降低。在肥胖状态下,发现唾液酸降解酶——唾液酸酶的活性增加。在接受治疗的肥胖患者的PMNL中,也证实了唾液酸含量和唾液酸酶活性的恢复。

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Mammalian sialidase (neuraminidase).哺乳动物唾液酸酶(神经氨酸酶)。
Biochem Biophys Res Commun. 1960 Nov;3:489-92. doi: 10.1016/0006-291x(60)90161-3.
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Altered erythrocyte Na+ + K+ pump in adolescent obesity.
Metabolism. 1982 Nov;31(11):1153-8. doi: 10.1016/0026-0495(82)90167-6.
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Chemistry, metabolism, and biological functions of sialic acids.唾液酸的化学、代谢及生物学功能
Adv Carbohydr Chem Biochem. 1982;40:131-234. doi: 10.1016/s0065-2318(08)60109-2.

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