Chari S N, Nath N
Am J Med Sci. 1984 Jul-Aug;288(1):18-20. doi: 10.1097/00000441-198407000-00003.
The level of sialic acid in the diabetic polymorphonuclear leucocytes was found to be significantly reduced as compared to normal. More pronounced effects were observed with ketoacidotic as compared to nonketoacidotic diabetic polymorphonuclear leucocytes. Activity of sialic acid degrading enzyme, sialidase, was found to be increased with more pronounced effect in the ketotic state. Diabetic patients treated either with intravenous insulin or oral hypoglycemic drugs showed restoration to normalcy in both sialic acid content and sialidase activity. The implications of the result are discussed.
与正常情况相比，发现糖尿病患者多形核白细胞中的唾液酸水平显著降低。与非酮症酸中毒的糖尿病多形核白细胞相比，酮症酸中毒时观察到的影响更为明显。发现唾液酸降解酶（唾液酸酶）的活性增加，在酮症状态下影响更为显著。接受静脉注射胰岛素或口服降糖药治疗的糖尿病患者，其唾液酸含量和唾液酸酶活性均恢复正常。讨论了该结果的意义。
