Bhatt Reena A, Rozental Tamara D
Department of Plastic Surgery, Warren Alpert Medical School of Brown University, The Miriam and Rhode Island Hospitals, 235 Plain Street, Providence, RI 02903, USA.
Hand Clin. 2012 Nov;28(4):457-68. doi: 10.1016/j.hcl.2012.08.001.
Replacement of missing bone stock is a reconstructive challenge to upper extremity surgeons and decision-making with regards to available choices remains difficult. Preference is often given to autograft in the form of cancellous, cortical, or corticocancellous grafts from donor sites. However, the available volume from such donor sites is limited and fraught with potential complications. Advances in surgical management and medical research have produced a wide array of potential substances that can be used for bone graft substitute. Considerations in selecting bone grafts and substitutes include characteristic capabilities, availability, patient morbidity, immunogenicity, potential disease transmission, and cost variability.
替代缺失的骨量是上肢外科医生面临的一项重建挑战，而在现有选择中进行决策仍然很困难。通常优先选择来自供区的松质骨、皮质骨或皮质松质骨形式的自体移植骨。然而，这些供区可获取的骨量有限，且充满潜在并发症。外科治疗和医学研究的进展产生了大量可用于骨移植替代物的潜在物质。选择骨移植材料和替代物时需要考虑的因素包括特性能力、可获得性、患者发病率、免疫原性、潜在疾病传播以及成本差异。
