Central Research Laboratory, Tokyo Innovation Center , Nippon Suisan Kaisha, Ltd. 32-3 Nanakuni 1 chome, Hachioji, Tokyo 192-0991, Japan.
J Nat Prod. 2012 Nov 26;75(11):1974-82. doi: 10.1021/np300719g. Epub 2012 Oct 26.
Nine new 26-membered macrolides of the oligomycin subfamily, neomaclafungins A-I, were isolated from the fermentation broth of Actinoalloteichus sp. NPS702, which was isolated from marine sediment collected from Usa Bay, Kochi Prefecture, Japan. Their structures were identified through mass spectrometry and NMR experiments. They belong to the oligomycin class and have several distinct features including the presence of alkane or alkanol branches. Neomaclafungins A-I exhibited significant antifungal activity in vitro against Trichophyton mentagrophytes (ATCC 9533), showing MIC values between 1 and 3 μg/mL.
从日本高知县宇佐湾采集的海洋沉积物中分离出的放线菌 Actinoalloteichus sp. NPS702 的发酵液中分离得到了 9 种新的 26 元大环内酯类寡霉素亚家族成员，即 neomaclafungins A-I。通过质谱和 NMR 实验确定了它们的结构。它们属于寡霉素类，具有几个明显的特征，包括存在烷烃或链烷醇支链。Neomaclafungins A-I 在体外对 Trichophyton mentagrophytes（ATCC 9533）表现出显著的抗真菌活性，MIC 值在 1 至 3 μg/mL 之间。
