Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan.
J Antibiot (Tokyo). 2020 Aug;73(8):534-541. doi: 10.1038/s41429-020-0304-7. Epub 2020 May 11.
Iseolides A-C (1-3), three new glycosylated macrolides, were identified from the culture extract of Streptomyces sp. DC4-5 isolated from a stony coral Dendrophyllia. Extensive analysis of one- and two-dimensional NMR data, coupled with MS/MS analytical data, revealed that iseolides are new congeners of 36-membered macrolides, PM100117 and PM100118, previously reported from a marine-derived Streptomyces. Iseolides showed potent antifungal activity against a plant pathogen Glomerella cingulata and human pathogens Candida albicans and Trichophyton rubrum with MIC in the range of 0.19-6.25 μg/mL.
Iseolides A-C（1-3）是从石珊瑚 Dendrophyllia 中分离出的链霉菌 sp. DC4-5 的培养物提取物中鉴定出的三种新的糖基化大环内酯。通过对一维和二维 NMR 数据的广泛分析，并结合 MS/MS 分析数据，揭示了 iseolides 是先前从海洋来源的链霉菌中报道的 36 元大环内酯 PM100117 和 PM100118 的新型同系物。Iseolides 对植物病原体炭疽菌和人类病原体白色念珠菌和红色毛癣菌表现出很强的抗真菌活性，MIC 范围在 0.19-6.25 μg/mL 之间。
