Cytotoxic and antimicrobial activities of secondary metabolites isolated from the deep-sea-derived 12A22.

UNLABELLED

A new deep-sea-derived actinomycete 12A22 was isolated from the sediment of the South China Sea which showed potential cytotoxic and antimicrobial activities. The actinomycete was identified as by investigating morphological characteristics and phylogenetic analyses based on its 16S rRNA gene sequence. Two compounds, cyclo-(-Pro--Pro--Tyr--Tyr) () and 2-hydroxyethyl-3-methyl-1,4-naphthoquinone (), were isolated and characterized from the fermentation broth of the strain 12A22. Compound exhibited significant inhibitory activities against a variety of phytopathogenic fungi ( f. sp. , , and ) and Gram-positive bacterium (). In particular, this compound showed better antifungal activity against than positive control amphotericin B. Besides, compound showed moderate cytotoxic activity against human breast cancer MDA-MB-435 cells with IC 10.59 µM, weaker than the positive control diaminedichloroplatinum with 5.91 μM. Our results suggested that this naphthoquinone could be used as a potential antimicrobial and antitumor agent.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s13205-021-02846-0.