McAuslan B R, Reilly W
J Cell Physiol. 1979 Dec;101(3):419-30. doi: 10.1002/jcp.1041010309.
A variant endothelial cell type was found to arise spontaneously from cultures of bovine aortal endothelial cells. This variant showed no contact inhibition and overgrew confluent cultures of wild-type endothelial cells. Unlike other reported variants of this cell type produced by chemical mutagenesis or by withdrawal of polypeptide growth factor, this variant retained the capacity to synthesis factor VIII antigen, but showed no alteration from wild-type in capacity to adsorb platelets. The variant also had an increased capacity to bind FITC-conjugated con A to its surface.
发现一种变异的内皮细胞类型可自发地从牛主动脉内皮细胞培养物中产生。这种变异细胞没有接触抑制现象，会在野生型内皮细胞的汇合培养物上过度生长。与其他通过化学诱变或去除多肽生长因子产生的该细胞类型变异体不同，这种变异体保留了合成因子VIII抗原的能力，但在吸附血小板的能力方面与野生型没有差异。该变异体还具有增强的将异硫氰酸荧光素（FITC）偶联的刀豆球蛋白A（con A）结合到其表面的能力。
