Takase S, Yasuhara M, Takada A, Ueshima Y
Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan.
Alcohol. 1990 Jan-Feb;7(1):37-41. doi: 10.1016/0741-8329(90)90058-k.
Serial changes in blood ethanol (Et-OH) and acetaldehyde (Ac-CHO) levels following a single oral administration of 0.8 g/kg of Et-OH were determined in order to clarify the metabolism of Ac-CHO in alcoholic liver disease (ALD). The Et-OH metabolic rate (EMR) in alcoholics either with or without liver disease was significantly higher than the rate in nonalcoholics. Peak values of blood Ac-CHO levels and the Ac-CHO/EMR ratios in ALD were significantly higher than those in subjects with nonALD or alcoholics and nonalcoholics without liver disease. In the type I aldehyde dehydrogenase isozyme deficient cases (unusual type), blood Ac-CHO levels and Ac-CHO/EMR ratios were very high and the levels remain at a plateau until 90 minutes after Et-OH administration and then decreased relatively quickly. Changes in blood Ac-CHO levels and Ac-CHO/EMR ratios in ALD were similar to those in cases of the unusual type. These results indicate that Ac-CHO metabolism in ALD is decreased relative to its production and that this decrease might be due to increased production of Ac-CHO in the nonalcohol dehydrogenase pathway located in the microsomes, in which degradation of Ac-CHO was slow.
为了阐明酒精性肝病（ALD）中乙醛（Ac-CHO）的代谢情况，对单次口服0.8 g/kg乙醇（Et-OH）后血液中乙醇（Et-OH）和乙醛（Ac-CHO）水平的系列变化进行了测定。患有或未患有肝病的酗酒者的乙醇代谢率（EMR）显著高于非酗酒者。ALD患者血液中乙醛水平的峰值以及乙醛/乙醇代谢率比值显著高于非ALD患者、酗酒者以及无肝病的非酗酒者。在I型醛脱氢酶同工酶缺乏病例（特殊类型）中，血液中乙醛水平和乙醛/乙醇代谢率比值非常高，且在乙醇给药后90分钟内保持在一个平台期，然后相对迅速下降。ALD患者血液中乙醛水平和乙醛/乙醇代谢率比值的变化与特殊类型病例相似。这些结果表明，ALD中乙醛代谢相对于其生成有所降低，这种降低可能是由于微粒体中非乙醇脱氢酶途径中乙醛生成增加，而乙醛在该途径中的降解缓慢。
