旧药新用：西地那非在伤口愈合中的潜在益处。

An old drug for a new application: potential benefits of sildenafil in wound healing.

机构信息

Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Pharm Pharm Sci. 2012;15(4):483-98. doi: 10.18433/j3tc7v.

DOI:10.18433/j3tc7v

PMID:23106952

Abstract

PURPOSE

Several studies have evaluated the effects of sildenafil on the tissue repair and wound healing. In the present review, the impact of sildenafil on the wound healing in all available clinical and non-clinical (experimental) studies has been discussed.

METHODS

A literature search was performed using PubMed, Scopus, Medline, Embase, Cochrane central register of controlled trials and Cochrane database systematic reviews. Related articles indexed in Google Scholar were also included. Key words used as search terms were 'phosphodiesterase inhibitor', 'sildenafil', 'skin', 'cutaneous', 'skin lesion', 'skin damage', 'wound', and 'wound healing'. No time limitation was considered in this review.

RESULTS

A total of 15 animal studies, 7 case reports, and 2 small clinical studies have reported the effects of sildenafil on the wound healing. The effects included skin flaps and grafts, anastomosis, systemic sclerosis and Raynaud's disease.

CONCLUSIONS

The available data support the beneficial effects of sildenafil in improvement of tissue healing in various conditions. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

摘要

目的

多项研究评估了西地那非对组织修复和伤口愈合的影响。在本次综述中，讨论了西地那非对所有现有临床和非临床（实验）研究中伤口愈合的影响。

方法

使用 PubMed、Scopus、Medline、Embase、Cochrane 对照试验中心注册库和 Cochrane 数据库系统评价进行文献检索。还包括在 Google Scholar 中索引的相关文章。用作搜索词的关键词是“磷酸二酯酶抑制剂”、“西地那非”、“皮肤”、“皮肤”、“皮肤损伤”、“皮肤病变”、“伤口”和“伤口愈合”。本综述未考虑时间限制。