申克孢子丝菌的吞噬作用及细胞内命运
Phagocytosis and intracellular fate of Sporothrix schenckii.
作者信息
Cunningham K M, Bulmer G S, Rhoades E R
出版信息
J Infect Dis. 1979 Nov;140(5):815-7. doi: 10.1093/infdis/140.5.815.
PMID:231073
Abstract
Human polymorphonuclear leukocytes (PMNLs) phagocytized and killed yeast-phase cells of Sporothrix schenckii in vitro in the presence of 10% unheated serum. The combination of H2O2, KI, and human PMNL myeloperoxidase was lethal to yeast-phase S. schenckii. The results of this investigation suggest that PMNLs may play an important role in host resistance to infection with S. schenckii.
摘要
在10%未加热血清存在的情况下，人多形核白细胞（PMNLs）在体外吞噬并杀死了申克孢子丝菌的酵母相细胞。过氧化氢、碘化钾和人PMNL髓过氧化物酶的组合对申克孢子丝菌的酵母相具有致死性。本研究结果表明，PMNLs可能在宿主抵抗申克孢子丝菌感染中发挥重要作用。
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