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申克孢子丝菌的吞噬作用及细胞内命运

Phagocytosis and intracellular fate of Sporothrix schenckii.

作者信息

Cunningham K M, Bulmer G S, Rhoades E R

出版信息

J Infect Dis. 1979 Nov;140(5):815-7. doi: 10.1093/infdis/140.5.815.

DOI:10.1093/infdis/140.5.815
PMID:231073
Abstract

Human polymorphonuclear leukocytes (PMNLs) phagocytized and killed yeast-phase cells of Sporothrix schenckii in vitro in the presence of 10% unheated serum. The combination of H2O2, KI, and human PMNL myeloperoxidase was lethal to yeast-phase S. schenckii. The results of this investigation suggest that PMNLs may play an important role in host resistance to infection with S. schenckii.

摘要

在10%未加热血清存在的情况下，人多形核白细胞（PMNLs）在体外吞噬并杀死了申克孢子丝菌的酵母相细胞。过氧化氢、碘化钾和人PMNL髓过氧化物酶的组合对申克孢子丝菌的酵母相具有致死性。本研究结果表明，PMNLs可能在宿主抵抗申克孢子丝菌感染中发挥重要作用。

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Phagocytosis and intracellular fate of Sporothrix schenckii.申克孢子丝菌的吞噬作用及细胞内命运
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Complement-Mediated Differential Immune Response of Human Macrophages to Species Through Interaction With Their Cell Wall Peptidorhamnomannans.
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J Fungi (Basel). 2019 Jan 11;5(1):8. doi: 10.3390/jof5010008.
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Current research on the immune response to experimental sporotrichosis.当前关于实验性孢子丝菌病免疫反应的研究。
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