Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Cont Lens Anterior Eye. 2013 Feb;36(1):28-31. doi: 10.1016/j.clae.2012.10.072. Epub 2012 Oct 26.
Irradiation by ultraviolet (UV) B is known to increase the number of Dopa-positive melanocytes in the skin. This study examines the effectiveness of a contact lens for the defense of UVB eye irradiation-induced pigmentation.
A 2.5 kJ/m(2) dose of UVB radiation was delivered by a sunlamp to the eye of C57BL/6j male mice, and changes in the expression of Dopa-positive melanocytes in the epidermis and the plasma level of alpha-melanocyte-stimulating hormone (α-MSH) was analyzed.
The degree of change in the Dopa-positive melanocytes expression was reduced by UVB blocking contact lens using mice given UVB irradiation to the eye. The plasma level of α-MSH increased in the C57BL/6j mice after irradiation to the eye, but there was no increase in the UVB blocking contact lens mice given UVB irradiation to the eye. Both the increase of the expression of Dopa-positive melanocytes and the plasma level of α-MSH were strongly suppressed by an alignment fitting UVB blocking contact lens and only a slightly suspended UVB blocking contact lens. In addition, these changes were successfully inhibited by a UVB blocking contact lens but not by a non-UVB blocking contact lens with a similar absorbance.
These observations suggest that the UVB blocking contact lens inhibits the pigmentation of the epidermis in mice by suppressing of the α-MSH.
已知紫外线（UV）B 照射可增加皮肤中多巴阳性黑素细胞的数量。本研究探讨了一种隐形眼镜在防御 UVB 眼部辐射诱导色素沉着方面的有效性。
通过太阳灯向 C57BL/6j 雄性小鼠的眼部照射 2.5 kJ/m(2)剂量的 UVB 辐射，分析表皮中多巴阳性黑素细胞表达的变化和血浆中α-促黑素细胞激素（α-MSH）的水平。
使用 UVB 阻断隐形眼镜减少了眼部接受 UVB 照射的小鼠中多巴阳性黑素细胞表达的变化程度。C57BL/6j 小鼠眼部接受照射后，α-MSH 的血浆水平增加，但眼部接受 UVB 照射的 UVB 阻断隐形眼镜小鼠中没有增加。两种排列贴合的 UVB 阻断隐形眼镜均能强烈抑制多巴阳性黑素细胞表达和 α-MSH 血浆水平的增加，而仅轻微悬挂的 UVB 阻断隐形眼镜则不能。此外，这些变化可被 UVB 阻断隐形眼镜抑制，但不能被具有相似吸收率的非 UVB 阻断隐形眼镜抑制。
这些观察结果表明，UVB 阻断隐形眼镜通过抑制 α-MSH 抑制了小鼠表皮的色素沉着。
