Hiramoto Keiichi, Yamate Yurika, Kawanishi Shosuke
Department of Pharmaceutical Science, Suzuka University of Medical Science, Suzuka, Japan; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Photodermatol Photoimmunol Photomed. 2015 May;31(3):124-8. doi: 10.1111/phpp.12143. Epub 2014 Nov 11.
It is known that the levels of hormones secreted from the pituitary gland are increased by ultraviolet B (UVB) eye irradiation. The ovaries are affected by the hormones secreted from the pituitary gland. Therefore, we observed the influence of UVB eye irradiation on the ovaries.
In this study, a 2.5 kJ/m(2) dose of UVB irradiation was delivered by a sunlamp to the eye or the ear of C57BL/6j female mice. Five days after UVB irradiation, we removed the ovaries.
The plasma levels of α-melanocyte-stimulating hormone (α-MSH), adrenocorticotropic hormone (ACTH), and β-endorphin were increased 24 h after UVB irradiation of either the eye or the ear. The amounts of ACTH and α-MSH were decreased 5 days after UVB irradiation. However, the β-endorphin level 5 days after UVB eye irradiation did not decrease. In addition, UVB eye irradiation increased the expression of dopa-positive cells, tyrosinase, and dopa decarboxylase, and also increased the immunoreactivity of melanocortin-1 receptor in the ovaries. The dopamine content in the plasma was also increased.
These results suggest that the melanin and dopamine systems of the ovary are affected by UVB eye irradiation, and the synthesized dopamine is maintained at high levels as β-endorphin.
已知紫外线B（UVB）照射眼睛会使垂体分泌的激素水平升高。卵巢会受到垂体分泌的激素的影响。因此，我们观察了UVB照射眼睛对卵巢的影响。
在本研究中，用紫外线灯对C57BL/6j雌性小鼠的眼睛或耳朵给予2.5 kJ/m²剂量的UVB照射。UVB照射5天后，我们摘除了卵巢。
对眼睛或耳朵进行UVB照射24小时后，血浆中α-黑素细胞刺激素（α-MSH）、促肾上腺皮质激素（ACTH）和β-内啡肽的水平升高。UVB照射5天后，ACTH和α-MSH的量减少。然而，UVB照射眼睛5天后β-内啡肽水平并未降低。此外，UVB照射眼睛增加了卵巢中多巴阳性细胞、酪氨酸酶和多巴脱羧酶的表达，也增加了黑皮质素-1受体的免疫反应性。血浆中的多巴胺含量也增加了。
这些结果表明，卵巢的黑色素和多巴胺系统受UVB照射眼睛的影响，合成的多巴胺以β-内啡肽的形式维持在高水平。
