Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
Eur J Gastroenterol Hepatol. 2013 Feb;25(2):135-41. doi: 10.1097/MEG.0b013e32835ae8f7.
In published studies, it has been suggested that dental wear is associated with gastroesophageal reflux disease (GERD). This systematic review was carried out to evaluate the association of GERD, dental erosion, and halitosis and to compare the indices adopted in epidemiological surveys. The Medline database (until October, 2011) was searched systematically to identify studies evaluating the prevalence of oral alterations, such as dental erosion and halitosis, in patients with GERD symptoms. Two reviewers analyzed all reports and the selected studies were evaluated according to the quality of evidence, using the validated Newcastle-Ottawa Quality Assessment Scale. Full-text copies of a total of 32 publications were obtained in duplicate. Sixteen publications were identified among the citations in the Bibliographic lists of studies that fulfilled the exclusion/inclusion criteria and quality of evidence. The relationship between dental erosion and GERD patients was significant in only seven studies. According to three studies, halitosis could be one of several extraesophageal symptoms or manifestations in GERD patients. In one study, it was found that the mucosa of GERD patients was significantly more acidic in comparison with that of the control group. This systematic review showed that there is a relationship between GERD and oral diseases (dental erosion and halitosis). The epidemiological surveys used different indices to analyze GERD and dental erosion. Further research could investigate the best method for assessing the two diseases.
在已发表的研究中，有人提出牙磨损与胃食管反流病（GERD）有关。本系统评价旨在评估 GERD、牙酸蚀和口臭之间的关系，并比较流行病学调查中采用的指标。系统地检索了 Medline 数据库（截至 2011 年 10 月），以确定评估 GERD 症状患者口腔改变（如牙酸蚀和口臭）患病率的研究。两位评审员分析了所有报告，并根据证据质量使用经过验证的纽卡斯尔-渥太华质量评估量表对选定的研究进行了评估。总共获得了 32 篇出版物的全文副本，其中有 16 篇是在符合排除/纳入标准和证据质量的研究参考文献中找到的。只有 7 项研究表明牙酸蚀与 GERD 患者之间存在显著关系。根据三项研究，口臭可能是 GERD 患者的食管外症状或表现之一。在一项研究中，发现与对照组相比，GERD 患者的黏膜酸度明显更高。本系统评价表明 GERD 与口腔疾病（牙酸蚀和口臭）之间存在关系。流行病学调查采用不同的指标来分析 GERD 和牙酸蚀。进一步的研究可以探讨评估这两种疾病的最佳方法。
