State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China.
Small. 2013 Feb 25;9(4):604-12. doi: 10.1002/smll.201201558. Epub 2012 Oct 30.
The synthesis of Au@mesoporous SiO(2)/rhodamine B isothiocyanate (Au@mSiO(2)/RBITC) composite nanoparticles (NPs) is presented and their unique biofunctional properties are studied. The structure and morphology of the NPs are characterized by X-ray powder diffraction, transmission electron microscopy, and Fourier transform infrared spectroscopy. These NPs can not only be functionalized for fluorescence imaging, but also possess well-defined mesopore structures for drug loading and strong infrared surface plasmon absorption for light-controlled drug release and photothermal therapy for cancer cells. In the biological experiments, one 808 nm laser is coupled to a confocal laser scanning microscopy (CLSM) system to monitor the photothermal therapy, drug release, and cell position and viability in real time by using the multichannel function of CLSM for the first time. Such novel nanomaterials offer a new chemotherapeutic route for cancer treatment by combining cell imaging and hyperthermia in a synergistic way.
金@介孔硅/若丹明 B 异硫氰酸酯（Au@mSiO（2）/RBITC）复合纳米粒子（NPs）的合成及其独特的生物功能特性研究。通过 X 射线粉末衍射、透射电子显微镜和傅里叶变换红外光谱对 NPs 的结构和形态进行了表征。这些 NPs 不仅可以进行荧光成像功能化，而且具有明确的介孔结构，可用于药物负载，以及强烈的红外表面等离激元吸收，用于光控药物释放和光热疗癌症细胞。在生物学实验中，首次使用共聚焦激光扫描显微镜（CLSM）的多通道功能，通过耦合一个 808nm 激光到 CLSM 系统，实时监测光热疗、药物释放以及细胞位置和活力。这种新型纳米材料为癌症治疗提供了一种新的化疗途径，通过协同作用将细胞成像和高热结合在一起。
