Broes Marieke J M, Roelofs Bob F W R, Mudde Aart H, Hoornenborg Elske
Jeroen Bosch Ziekenhuis, afd. Interne Geneeskunde, 's-Hertogenbosch, the Netherlands.
Ned Tijdschr Geneeskd. 2012;156(44):A4990.
Acute pulmonary syndrome is an uncommon but severe adverse reaction to nitrofurantoin. This syndrome is seldom recognised at the moment of presentation, which potentially subjects patients to unnecessary treatment and delays in the discontinuation of nitrofurantoin. We discuss the case histories of an 80-year-old and an 81-year-old woman, each presenting with acute pulmonary syndrome after nitrofurantoin administration. The diagnosis of acute pulmonary syndrome should be considered in patients presenting with fever, dyspnoea, dry cough, leukocytosis (typically with eosinophilia) and a bilateral interstitial pattern visible on the chest X-ray after having started nitrofurantoin. The prognosis is excellent if the condition is recognised early and the exposure to nitrofurantoin is discontinued.
急性肺综合征是对呋喃妥因罕见但严重的不良反应。该综合征在出现时很少被识别，这可能使患者接受不必要的治疗，并延迟呋喃妥因的停用。我们讨论了一名80岁和一名81岁女性的病例史，她们在服用呋喃妥因后均出现急性肺综合征。在开始使用呋喃妥因后，出现发热、呼吸困难、干咳、白细胞增多（通常伴有嗜酸性粒细胞增多）以及胸部X线显示双侧间质模式的患者，应考虑急性肺综合征的诊断。如果病情早期得到识别并停止接触呋喃妥因，预后良好。
