Madani Yasser, Mann Bhupinder
Department of Respiratory Medicine, West Middlesex University Hospital, London, UK.
Prim Care Respir J. 2012 Sep;21(3):337-41. doi: 10.4104/pcrj.2012.00059.
Nitrofurantoin is commonly used for the treatment and prophylaxis of recurrent urinary tract infections (UTIs). Although relatively rare, nitrofurantoin is one of the commonest causes of drug-induced pulmonary disease, which can be potentially serious and even fatal. Knowledge of such potential adverse effects is essential to enable early recognition and withdrawal of the drug. Patients on long-term nitrofurantoin should be reviewed and monitored regularly. Management involves early consideration of the condition, and prompt withdrawal of the drug. We report three cases of nitrofurantoin-induced lung disease in patients who were on long-term nitrofurantoin for UTI prophylaxis and present a brief review of the literature on this subject.
呋喃妥因常用于复发性尿路感染（UTIs）的治疗和预防。尽管相对罕见，但呋喃妥因是药物性肺病最常见的病因之一，可能会很严重甚至致命。了解此类潜在不良反应对于早期识别和停用该药物至关重要。长期服用呋喃妥因的患者应定期复查和监测。处理措施包括尽早考虑病情，并迅速停用药物。我们报告了3例因长期服用呋喃妥因预防UTIs而导致肺病的病例，并对该主题的文献进行简要综述。
