National Neuroscience Institute, Department of Neurology, Singapore General Hospital, Singapore, Singapore.
Mov Disord. 2012 Dec;27(14):1729-37. doi: 10.1002/mds.25197. Epub 2012 Oct 31.
The link between Parkinson's disease (PD) and certain primary sleep disorders has yet to be clarified. We performed a systematic review of case-control polysomnography studies to evaluate the relationship between PD and sleep disorders. A PubMed literature search and bibliography review yielded 15 case-control polysomnography studies in patients with PD. Studies differed by recruitment methods, duration of polysomnography monitoring, and sleep parameters measured. Subjective sleepiness was greater in patients than controls (50%-66% vs 2.9%-12%) despite lack of objective increase in daytime sleepiness by mean sleep latency testing. The 4 case-control polysomnography studies investigating rapid eye movement behavior disorder support a higher prevalence in PD (0%-47% vs 0%-1.8% in controls), although differences in diagnostic criteria hamper interpretation. The preponderance of evidence did not support an increased incidence of obstructive sleep apnea (27%-60% vs 13%-65%) or periodic leg movements of sleep in patients compared to controls. Adequately powered, prospective studies with uniform methodology and healthy controls are needed to further address the association and pathophysiological significance between PD and sleep problems.
帕金森病（PD）与某些原发性睡眠障碍之间的联系尚未阐明。我们进行了一项系统的病例对照睡眠多导图研究综述，以评估 PD 与睡眠障碍之间的关系。通过 PubMed 文献检索和参考文献综述，共获得了 15 项 PD 患者的病例对照睡眠多导图研究。研究的差异在于招募方法、睡眠监测持续时间和测量的睡眠参数。尽管通过平均睡眠潜伏期测试未发现白天嗜睡的客观增加，但患者的主观嗜睡程度高于对照组（50%-66% vs 2.9%-12%）。4 项研究 REM 行为障碍的病例对照睡眠多导图研究支持 PD 中患病率更高（0%-47% vs 对照组 0%-1.8%），尽管诊断标准的差异影响了解释。大多数证据不支持与对照组相比，患者的阻塞性睡眠呼吸暂停（27%-60% vs 13%-65%）或睡眠周期性肢体运动增多。需要采用统一方法和健康对照的、充分有力的前瞻性研究来进一步探讨 PD 和睡眠问题之间的关联和病理生理意义。
