Department of Genetics and Molecular Biology, Medical School of Xi'an Jiaotong University, Xi'an, China.
Dis Model Mech. 2012 Nov;5(6):763-71. doi: 10.1242/dmm.008961.
Multiple myeloma (MM) is the second most common hematological malignancy and is characterized by the clonal expansion of plasma cells in the bone marrow. Recently, hypoxia has received increased interest in the context of MM, in both basic and translational research. In this review, we describe the discovery of the hypoxic niche in MM and how it can be targeted therapeutically. We also discuss mouse models that closely mimic human MM, highlighting those that allow preclinical research into new therapies that exploit the hypoxic niche in MM.
多发性骨髓瘤（MM）是第二大常见血液系统恶性肿瘤，其特征是骨髓中浆细胞的克隆性扩张。最近，缺氧在 MM 的基础和转化研究中受到了越来越多的关注。在这篇综述中，我们描述了 MM 中缺氧小生境的发现以及如何对其进行治疗性靶向。我们还讨论了与人类 MM 非常相似的小鼠模型，突出了那些允许对利用 MM 缺氧小生境的新疗法进行临床前研究的模型。
