SNX17 有助于多种乳头瘤病毒类型的感染。
SNX17 facilitates infection with diverse papillomavirus types.
机构信息
International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
出版信息
J Virol. 2013 Jan;87(2):1270-3. doi: 10.1128/JVI.01991-12. Epub 2012 Oct 31.
Abstract
Previous studies have shown that the human papillomavirus type 16 (HPV-16) L2 capsid protein plays an essential role in viral infection, in part through its interaction with sorting nexin 17 (SNX17). We now show that this interaction between L2 and SNX17 is conserved across multiple PV types. Furthermore, we demonstrate that SNX17 is essential for infection with all PV types analyzed, indicating an evolutionarily highly conserved virus entry mechanism.
摘要
先前的研究表明，人乳头瘤病毒 16 型（HPV-16）L2 衣壳蛋白在病毒感染中起着至关重要的作用，部分原因是它与分选连接蛋白 17（SNX17）相互作用。我们现在表明，L2 和 SNX17 之间的这种相互作用在多种 PV 类型中是保守的。此外，我们证明 SNX17 对于所有分析的 PV 类型的感染都是必不可少的，这表明存在一种进化上高度保守的病毒进入机制。
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