(retromer 和分选连接蛋白在病毒生命周期中的新兴作用)。
The emerging roles of retromer and sorting nexins in the life cycle of viruses.
机构信息
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250013, China; Department of Pathogen Biology, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
Department of Pathogen Biology, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
出版信息
Virol Sin. 2022 Jun;37(3):321-330. doi: 10.1016/j.virs.2022.04.014. Epub 2022 May 2.
Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of retromer/SNXs, such as Vps35, Vps26, SNX5 and SNX27, can affect multiple steps of the viral life cycle, including facilitating the entry of viruses into cells, participating in viral replication, and promoting the assembly of virions. Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus, which will shed mechanistic insights into controlling virus infection.
返回蛋白和衔接蛋白（SNXs）将 cargo 从内体运输到反式高尔基体网络或质膜。最近的研究揭示了返回蛋白和 SNXs 在病毒生命周期中的新兴作用，包括冠状病毒科、黄病毒科和逆转录病毒科的成员。返回蛋白/SNXs 的关键成分，如 Vps35、Vps26、SNX5 和 SNX27，可以影响病毒生命周期的多个步骤，包括促进病毒进入细胞、参与病毒复制以及促进病毒粒子的组装。在这里，我们全面更新了返回蛋白/SNXs 与病毒相互作用的综述，这将为控制病毒感染提供机制上的见解。
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