季节性三价灭活流感疫苗不能预防雪貂体内新型甲型流感（H3N2v）病毒。
Seasonal trivalent inactivated influenza vaccine does not protect against newly emerging variants of influenza A (H3N2v) virus in ferrets.
机构信息
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
出版信息
J Virol. 2013 Jan;87(2):1261-3. doi: 10.1128/JVI.02625-12. Epub 2012 Oct 31.
Abstract
The recent increase in human cases of influenza A H3N2 variant virus [A(H3N2)v] highlights the need to assess whether seasonal influenza vaccination provides cross-protection against A(H3N2)v virus. Our data demonstrate that the 2011-2012 trivalent inactivated influenza vaccine (TIV) protected ferrets against homologous H3N2 virus challenge but provided minimal to no protection against A(H3N2)v virus. The complete absence of specific hemagglutination inhibition antibody response to A(H3N2)v is consistent with the poor cross-protection observed among TIV-immune animals.
摘要
最近，人类感染甲型 H3N2 流感变异病毒（A(H3N2)v）的病例有所增加，这凸显了评估季节性流感疫苗是否对 A(H3N2)v 病毒提供交叉保护的必要性。我们的数据表明，2011-2012 年三价灭活流感疫苗（TIV）能保护雪貂免受同源 H3N2 病毒的攻击，但对 A(H3N2)v 病毒的保护作用极小或没有。针对 A(H3N2)v 的特异性血凝抑制抗体反应完全缺失，与 TIV 免疫动物中观察到的交叉保护作用不佳相一致。
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1
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MMWR Morb Mortal Wkly Rep. 2012 Aug 17;61(32):619-21.
2
Notes from the field: Outbreak of influenza A (H3N2) virus among persons and swine at a county fair--Indiana, July 2012.现场记录：印第安纳州县集市发生的人感染甲型 H3N2 流感病毒和猪感染流感病毒疫情——2012 年 7 月。
MMWR Morb Mortal Wkly Rep. 2012 Jul 27;61(29):561.
3
Update: influenza activity - United States, 2011-12 season and composition of the 2012-13 influenza vaccine.更新：流感活动-美国，2011-12 季节和 2012-13 流感疫苗的组成。
MMWR Morb Mortal Wkly Rep. 2012 Jun 8;61(22):414-20.
4
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5
Human infections with novel reassortant influenza A(H3N2)v viruses, United States, 2011.2011 年美国新型重配甲型 H3N2 流感病毒感染人类。
Emerg Infect Dis. 2012 May;18(5):834-7. doi: 10.3201/eid1805.111922.
6
7
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8
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Euro Surveill. 2012 Jan 26;17(4):20066. doi: 10.2807/ese.17.04.20066-en.
9
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MMWR Morb Mortal Wkly Rep. 2012 Jan 6;60(51-52):1741-4.
10
Genetic analysis and antigenic characterization of swine origin influenza viruses isolated from humans in the United States, 1990-2010.美国 1990-2010 年从人分离的猪源流感病毒的遗传分析和抗原特征。
Virology. 2012 Jan 5;422(1):151-60. doi: 10.1016/j.virol.2011.10.016. Epub 2011 Nov 10.
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