Department of Anesthesiology and Pain Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Korean J Anesthesiol. 2012 Oct;63(4):353-6. doi: 10.4097/kjae.2012.63.4.353. Epub 2012 Oct 12.
Many medical institutions in Korea have recently been performing an antibody screening test as one of the essential elements of a pre-transfusion test. The Di(a) antigen is well known as one of the antigens with low incidence among Caucasians; however, it has been discovered with a relatively higher incidence among Mongoloid populations. The frequency of the Di(a) antigen among the Korean population is estimated to be 6.4-14.5%. But in Korea, a screening panel of cells from abroad without Di(a) positive cells has been commonly used when a patient has an unexpected antibody screening test. Here we report a case of acute hemolytic transfusion reaction due to Anti-Di(a) antibody. To prevent other transfusion reaction by anti-Di(a) antibody, addition of Di(a) positive cells as unexpected antibody screening test is recommended.
韩国的许多医疗机构最近一直在进行抗体筛选测试，作为输血前测试的基本要素之一。Di(a)抗原是众所周知的在白种人群体中发生率较低的抗原之一；然而，在蒙古人群体中，其发生率相对较高。韩国人群中 Di(a)抗原的频率估计为 6.4-14.5%。但是在韩国，当患者出现意外的抗体筛选测试时，通常会使用来自国外没有 Di(a)阳性细胞的筛选细胞板。在这里，我们报告了一例由于抗 Di(a)抗体引起的急性溶血性输血反应。为了防止因抗 Di(a)抗体引起的其他输血反应，建议在意外抗体筛选测试中添加 Di(a)阳性细胞。
