Lee Yun-Ah, Kang Sung-Goo, Kim Se-Hong, Park Seo-Jin, Kim Ha-Na, Song In-Sun, Song Sang-Wook
Department of Family Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Korean J Fam Med. 2012 Sep;33(5):296-304. doi: 10.4082/kjfm.2012.33.5.296. Epub 2012 Sep 27.
As many studies revealed that oxidative stress due to the imbalance of reactive oxygen species (ROS) and antioxidant capacity is related with pathologic processes such as cardiovascular diseases, diabetes, as well as aging and obesity, the relationship between lifestyle and oxidative stress has recently gained much medical attention. However, little information exists on the effects of lifestyle on ROS in Korea. In this study, we investigated the effects of lifestyle on free oxygen radical levels in men and women in Korea.
A total of 138 adults participated in this study from September 2007 to June 2010 at a health promotion center and department of family medicine. Information on the lifestyle of each participant was obtained by questionnaire. Biochemical markers and a free oxygen radical test (FORT) were also measured.
The average age was 47.28 ± 10.85 years and 79.7% were male. High sensitivity C-reactive protein (hs-CRP; r = 0.418, P = 0.012), triglycerides (r = -0.243, P = 0.008), hemoglobin (r = -0.445, P < 0.001), total protein (r = 0.210, P = 0.036), creatinine (r = -0.294, P = 0.001), fruit intake per day (P = 0.047), and smoking (P = 0.003) were related to the FORT levels in univariate analysis. Multiple linear regression analysis showed that hs-CRP (P = 0.039) was an independent predictor of serum FORT values. This statistical model can explain 78% of the variance in FORT values.
This result suggests that hs-CRP showed a statistically significant positive association with FORT values. Further studies on the relationship between lifestyle and antioxidant capacity as well as ROS seem to be warranted to evaluate the overall effect of oxidative stress.
许多研究表明，由于活性氧（ROS）与抗氧化能力失衡导致的氧化应激与心血管疾病、糖尿病以及衰老和肥胖等病理过程相关，生活方式与氧化应激之间的关系最近备受医学关注。然而，关于韩国生活方式对ROS影响的信息却很少。在本研究中，我们调查了韩国男性和女性生活方式对游离氧自由基水平的影响。
2007年9月至2010年6月，共有138名成年人在一家健康促进中心和家庭医学科参与了本研究。通过问卷调查获取每位参与者的生活方式信息。还测量了生化指标和游离氧自由基测试（FORT）。
平均年龄为47.28±10.85岁，男性占79.7%。在单因素分析中，高敏C反应蛋白（hs-CRP；r = 0.418，P = 0.012）、甘油三酯（r = -0.243，P = 0.008）、血红蛋白（r = -0.445，P < 0.001）、总蛋白（r = 0.210，P = 0.036）、肌酐（r = -0.294，P = 0.001）、每日水果摄入量（P = 0.047）和吸烟（P = 0.003）与FORT水平相关。多元线性回归分析表明，hs-CRP（P = 0.039）是血清FORT值的独立预测因子。该统计模型可以解释FORT值中78%的变异。
该结果表明hs-CRP与FORT值之间存在统计学上显著的正相关。关于生活方式与抗氧化能力以及ROS之间关系的进一步研究似乎有必要，以评估氧化应激的总体影响。
