配体促进的 Pd(II)催化剂引发的亚甲基 C(sp3)-H 键活化。
Ligand-enabled methylene C(sp3)-H bond activation with a Pd(II) catalyst.
机构信息
Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
出版信息
J Am Chem Soc. 2012 Nov 14;134(45):18570-2. doi: 10.1021/ja309325e. Epub 2012 Nov 5.
Abstract
Pd(II) insertion into β-methylene C(sp(3))-H bonds was enabled by a mutually repulsive and electron-rich quinoline ligand. Ligand tuning led to the development of a method that allows for installation of an aryl group on a range of acyclic and cyclic amides containing β-methylene C(sp(3))-H bonds.
摘要
通过一个相互排斥且富电子的喹啉配体，实现了 Pd(II) 插入β-亚甲基 C(sp(3))-H 键。通过配体调谐，开发出了一种方法，可以在含有β-亚甲基 C(sp(3))-H 键的一系列非环和环状酰胺上安装芳基。
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