钯(II)催化剂促进的 C(sp )-H 键的配体辅助炔基化反应。
Ligand-Enabled Alkynylation of C(sp )-H Bonds with Palladium(II) Catalysts.
机构信息
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
出版信息
Angew Chem Int Ed Engl. 2017 Feb 6;56(7):1873-1876. doi: 10.1002/anie.201610426. Epub 2017 Jan 12.
Abstract
The palladium(II)-catalyzed β- and γ-alkynylation of amide C(sp )-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing α-tertiary or α-quaternary carbon centers. The β-methylene C(sp )-H bonds of various carbocyclic rings were also successfully alkynylated.
摘要
钯(II)催化酰胺 C(sp )-H 键的 β-和 γ-炔基化反应可通过吡啶基配体实现。该炔基化反应与含有 α-三级或 α-四级碳原子中心的底物兼容。各种碳环的β-亚甲基 C(sp )-H 键也可成功进行炔基化。
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