曲霉属中一个簇的分子遗传特征，用于合成倍半萜烯 terretonin。
Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin.
机构信息
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA.
出版信息
Org Lett. 2012 Nov 16;14(22):5684-7. doi: 10.1021/ol302682z. Epub 2012 Nov 1.
Abstract
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.
摘要
倍半萜类化合物是由聚酮和萜烯前体产生的天然产物。我们为 A. terreus NIH2624 开发了一种基因靶向系统，并对 terretonin 生物合成基因簇进行了表征。我们从突变株中分离出中间体和分流产物，并提出了 terretonin 生物合成途径。对 A. terreus 中的 terretonin 和 A. nidulans 中的 austinol 对应的两条倍半萜类化合物途径进行分析表明，它们在进化上密切相关。
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