特瑞醇 D1，一种新型海洋来源 ML-44 衍生的倍半萜烯类化合物。
Terretonin D1, a new meroterpenoid from marine-derived ML-44.
机构信息
a Institute of Neuroscience and Translational Medicine, College of Life Science and Agronomy , Zhoukou Normal University , Zhoukou , China.
b School of Pharmacy , Nantong University , Nantong , China.
出版信息
Nat Prod Res. 2019 Aug;33(15):2262-2265. doi: 10.1080/14786419.2018.1493583. Epub 2018 Nov 3.
A new meroterpenoid, named terretonin D1 (), and three known ones, terretonin (), terretonin A (), and terretonin D (), were isolated from marine-derived fungus ML-44. The structure of was elucidated by extensive spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and the absolute configuration was determined by X-ray crystallographic analysis. The anti-inflammation activity of - was preliminarily tested, and all of them weakly inhibited the nitric oxide (NO) production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS), with inhibitory rates of 22-34% at 50 μg/mL.
从海洋来源的真菌 ML-44 中分离得到了一种新的倍半萜烯化合物，命名为 terretonin D1 ()，以及三种已知化合物 terretonin ()、terretonin A () 和 terretonin D ()。通过广泛的光谱方法，包括 1D 和 2D NMR、HR-ESI-MS，阐明了 的结构，并通过 X 射线晶体学分析确定了其绝对构型。对 - 的抗炎活性进行了初步测试，它们均微弱抑制脂多糖 (LPS) 刺激的 RAW264.7 巨噬细胞中一氧化氮 (NO) 的产生，在 50 μg/mL 时抑制率为 22-34%。
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