后基因组时代曲霉属次级代谢产物研究进展。
Advances in Aspergillus secondary metabolite research in the post-genomic era.
机构信息
University of Southern California-Pharmacology and Pharmaceutical Sciences, Los Angeles, California 90033, USA.
出版信息
Nat Prod Rep. 2012 Mar;29(3):351-71. doi: 10.1039/c2np00084a. Epub 2012 Jan 6.
Abstract
This review studies the impact of whole genome sequencing on Aspergillus secondary metabolite research. There has been a proliferation of many new, intriguing discoveries since sequencing data became widely available. What is more, the genomes disclosed the surprising finding that there are many more secondary metabolite biosynthetic pathways than laboratory research had suggested. Activating these pathways has been met with some success, but many more dormant genes remain to be awakened.
摘要
这篇综述研究了全基因组测序对曲霉属次级代谢产物研究的影响。自从测序数据广泛可用以来，出现了许多新的、有趣的发现。更重要的是，基因组揭示了一个令人惊讶的发现，即次级代谢产物生物合成途径比实验室研究所暗示的要多得多。激活这些途径已经取得了一些成功，但仍有许多休眠基因有待唤醒。
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