Versteegh F G, Bogaard J M, Raatgever J W, Stam H, Neijens H J, Kerrebijn K F
Dept of Paediatrics, Erasmus University, Rotterdam, The Netherlands.
Eur Respir J. 1990 Jan;3(1):68-73.
We measured pulmonary function, responses to exercise and oxygen saturation (So2) at rest, and also before and during sleep in 24 patients with cystic fibrosis in a varying degree of severity. The pulmonary function indices analysed were forced expiratory volume in one second (FEV1), total lung capacity (TLC), measured by body plethysmography (TLC box) and Helium dilution (TLC He), residual volume measured by body plethysmography (RV) and the amount of trapped air (TA = TLC box-TLC He). The exercise variables included symptom limited maximal oxygen uptake (Vo2max), maximum minute ventilation (VEmax) and So2, at rest in sitting position and during maximal exercise. So2 was measured by ear oximetry. The lowest mean So2 obtained in two consecutive nights over a period of 1 hour was taken as the indicator of nocturnal oxygen saturation. A high correlation existed between resting supine and sitting So2, and the degree of nocturnal hypoxaemia (0.84 and 0.76, respectively). Highly significant correlations existed also for the indices of airway obstruction, Vo2 max and lowest So2 at exercise versus the nocturnal lowest hourly mean So2. From all variables a resting So2 in the sitting position lower than 94% appeared to be most predictive of nocturnal desaturation and indicates a risk of nocturnal hypoxaemia in patients with cystic fibrosis.
我们对24例病情严重程度各异的囊性纤维化患者进行了肺功能、运动反应及静息、睡眠前和睡眠期间的血氧饱和度（So2）测定。分析的肺功能指标包括一秒用力呼气量（FEV1）、通过体容积描记法（TLC盒）和氦稀释法（TLC He）测量的肺总量（TLC）、通过体容积描记法测量的残气量（RV）以及滞留气量（TA = TLC盒 - TLC He）。运动变量包括症状受限的最大摄氧量（Vo2max）、最大分钟通气量（VEmax）以及静息坐位和最大运动期间的So2。So2通过耳血氧饱和度测定法测量。连续两晚1小时内获得的最低平均So2被用作夜间血氧饱和度的指标。静息仰卧位和坐位的So2与夜间低氧血症程度之间存在高度相关性（分别为0.84和0.76）。气道阻塞指标、运动时的Vo2 max和最低So2与夜间最低每小时平均So2之间也存在高度显著的相关性。在所有变量中，坐位静息So2低于94%似乎最能预测夜间血氧饱和度下降，并表明囊性纤维化患者存在夜间低氧血症风险。
