Brogelli L, Moretti S, Borgognoni L, Giannotti B
Clinica Dermatologica II, Università di Firenze, Italia.
Dermatologica. 1990;180(2):69-72. doi: 10.1159/000247993.
It was recently demonstrated that HLA-DR antigens in primary melanomas are correlated with 96-K antigen expression and with the presence of an intratumoral lymphocytic infiltrate (ILI). As HLA-DR antigens are known to be associated with advanced phases of tumor progression in melanocytic lesions, we investigated whether primary melanomas in different progression phases could be distinguished on the basis of the expression of HLA-DR and 96-K antigens and of the presence of an ILI. A concordant presence of the two antigens and of an ILI was frequent both in vertical growth pattern melanomas and in melanomas thicker than 1 mm. On the contrary, both antigens and the ILI were frequently absent both in thin melanomas (less than 1 mm) and in radial growth pattern melanomas. These observations suggest that a joint study of HLA-DR and 96-K antigens and of the ILI is useful to define the phase of progression of primary melanomas.
最近有研究表明，原发性黑色素瘤中的HLA - DR抗原与96 - K抗原表达以及瘤内淋巴细胞浸润（ILI）有关。由于已知HLA - DR抗原与黑素细胞病变中肿瘤进展的晚期阶段相关，我们研究了是否可以根据HLA - DR和96 - K抗原的表达以及ILI的存在来区分不同进展阶段的原发性黑色素瘤。在垂直生长模式的黑色素瘤和厚度超过1毫米的黑色素瘤中，两种抗原和ILI同时存在的情况很常见。相反，在薄的黑色素瘤（小于1毫米）和放射状生长模式的黑色素瘤中，这两种抗原和ILI常常都不存在。这些观察结果表明，联合研究HLA - DR和96 - K抗原以及ILI有助于确定原发性黑色素瘤的进展阶段。
