20(S)-人参皂苷 Rg3 对链脲佐菌素诱导的实验性 2 型糖尿病大鼠的影响：快速分辨液相色谱/质谱联用的尿代谢组学研究。
Effect of 20(S)-ginsenoside Rg3 on streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study by rapid-resolution liquid chromatography/mass spectrometry.
机构信息
Changchun Center of Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
出版信息
Rapid Commun Mass Spectrom. 2012 Dec 15;26(23):2683-9. doi: 10.1002/rcm.6392.
RATIONALE
20(S)-ginsenoside Rg3 is an active component of Panax ginseng. It is known that 20(S)-ginsenoside Rg3 has a protective effect against hyperglycemia, obesity and diabetes in vivo, but the precise mechanisms of these actions have not yet been entirely elucidated.
METHODS
A urinary metabonomics method based on rapid-resolution liquid chromatography/mass spectrometry (RRLC/MS) was developed to investigate the effect of 20(S)-ginsenoside Rg3 on type 2 diabetic rats.
RESULTS
With multivariate statistical analysis, a clear separation between type 2 diabetic rats and those treated with 20(S)-ginsenoside Rg3 was achieved. Six potential biomarkers were found and identified.
CONCLUSIONS
This work shows that the mechanism of the effect of 20(S)-ginsenoside Rg3 on type 2 diabetes may be involved with the regulation of nucleic acid metabolism, energy metabolism and gut flora metabolism.
理由
20(S)-人参皂苷 Rg3 是人参的一种活性成分。已知 20(S)-人参皂苷 Rg3 对体内高血糖、肥胖和糖尿病具有保护作用，但这些作用的确切机制尚未完全阐明。
方法
建立了一种基于快速分辨液相色谱/质谱（RRLC/MS）的尿代谢组学方法，用于研究 20(S)-人参皂苷 Rg3 对 2 型糖尿病大鼠的作用。
结果
通过多变量统计分析，成功实现了 2 型糖尿病大鼠与 20(S)-人参皂苷 Rg3 治疗组之间的明显分离。发现并鉴定了 6 个潜在的生物标志物。
结论
本工作表明，20(S)-人参皂苷 Rg3 对 2 型糖尿病的作用机制可能涉及核酸代谢、能量代谢和肠道菌群代谢的调节。
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