Department of Sports and Exercise Medicine, Institute of Clinical Medicine, University of Helsinki, Paasikivenkatu 4, 00250 Helsinki, Finland.
Eur J Appl Physiol. 2013 May;113(5):1181-8. doi: 10.1007/s00421-012-2532-4. Epub 2012 Nov 6.
Blood O₂ carrying capacity affects aerobic capacity (VO₂max). Patients with type 1 diabetes have a risk for anaemia along with renal impairment, and they often have low VO₂max. We investigated whether total haemoglobin mass (tHb-mass) and blood volume (BV) differ in men with type 1 diabetes (T1D, n = 12) presently without complications and in healthy men (CON, n = 23) (age-, anthropometry-, physical activity-matched), to seek an explanation for low VO₂max. We determined tHb-mass, BV, haemoglobin concentration ([Hb]), and VO₂max in T1D and CON. With similar (mean ± SD) [Hb] (144 vs. 145 g l(-1)), T1D had lower tHb-mass (10.1 ± 1.4 vs. 11.0 ± 1.1 g kg(-1), P < 0.05), BV (76.8 ± 9.5 vs. 83.5 ± 8.3 ml kg(-1), P < 0.05) and VO₂max (35.4 ± 4.8 vs. 44.9 ± 7.5 ml kg(-1) min(-1), P < 0.001) than CON. VO₂max correlated with tHb-mass and BV both in T1D (r = 0.71, P < 0.01 and 0.67, P < 0.05, respectively) and CON (r = 0.54, P < 0.01 and 0.66, P < 0.001, respectively), but not with [Hb]. Linear regression slopes were shallower in T1D than CON both between VO₂max and tHb-mass (2.4 and 3.6 ml kg(-1) min(-1) vs. g kg(-1), respectively) and VO₂max and BV (0.3 and 0.6 ml kg(-1) min(-1) vs. g kg(-1), respectively), indicating that T1D were unable to reach similar VO₂max than CON at a given tHb-mass and BV. In conclusion, low tHb-mass and BV partly explained low VO₂max in T1D and may provide early and more sensitive markers of blood O₂ carrying capacity than [Hb] alone.
血液氧载量影响有氧能力（最大摄氧量，VO₂max）。1 型糖尿病患者存在贫血和肾功能损害的风险，他们的 VO₂max 往往较低。我们研究了 12 名目前无并发症的 1 型糖尿病（T1D）男性和 23 名健康男性（CON）（年龄、人体测量、体力活动匹配）的总血红蛋白质量（tHb-mass）和血容量（BV）是否存在差异，以寻求低 VO₂max 的解释。我们在 T1D 和 CON 中确定了 tHb-mass、BV、血红蛋白浓度（[Hb]）和 VO₂max。尽管 [Hb]（144 与 145 g l(-1)）相似，T1D 的 tHb-mass（10.1 ± 1.4 与 11.0 ± 1.1 g kg(-1)，P < 0.05）、BV（76.8 ± 9.5 与 83.5 ± 8.3 ml kg(-1)，P < 0.05）和 VO₂max（35.4 ± 4.8 与 44.9 ± 7.5 ml kg(-1) min(-1)，P < 0.001）均低于 CON。T1D 和 CON 中 VO₂max 均与 tHb-mass 和 BV 相关（r = 0.71，P < 0.01 和 0.67，P < 0.05），但与 [Hb]无关。T1D 与 CON 之间，VO₂max 与 tHb-mass（分别为 2.4 和 3.6 ml kg(-1) min(-1) 与 g kg(-1)）和 VO₂max 与 BV（分别为 0.3 和 0.6 ml kg(-1) min(-1) 与 g kg(-1)）之间的线性回归斜率更平缓，表明 T1D 无法达到与 CON 相似的 VO₂max，而 BV 和 tHb-mass 相同。综上所述，低 tHb-mass 和 BV 部分解释了 T1D 中低 VO₂max，并且可能比 [Hb]单独提供更早期和更敏感的血液氧载量标志物。
