Enger S C, Erikssen J
Scand J Clin Lab Invest. 1979 Nov;39(7):627-34. doi: 10.3109/00365517909108867.
Coronary heart disease (CHD) risk factors were studied in presumably healthy men, examined for preclinical CHD. Coronary angiography was performed in most "latent CHD" subjects. High density lipoprotein (HDL) cholesterol and apoproteins did not differ significantly between men with latent CHD (some with angiographic changes) and men without evidence of CHD. HDL cholesterol was positively correlated with physical activity. Insulin secretion was, however, positively associated with physical inactivity, body weight and serum triglycerides. Men with the highest insulin secretion had the lowest glucose tolerance. The study confirms the covariance between HDL cholesterol, insulin secretion, serum triglycerides, body weight and physical activity, but does not support the theory that HDL is a major "negative risk factor" in middle-aged men with preclinical CHD.
对疑似健康的男性进行了冠心病（CHD）危险因素的研究，这些男性接受了临床前冠心病检查。大多数“潜伏性冠心病”受试者进行了冠状动脉造影。潜伏性冠心病患者（部分有血管造影改变）与无冠心病证据的男性之间，高密度脂蛋白（HDL）胆固醇和载脂蛋白没有显著差异。HDL胆固醇与体力活动呈正相关。然而，胰岛素分泌与体力活动不足、体重和血清甘油三酯呈正相关。胰岛素分泌最高的男性葡萄糖耐量最低。该研究证实了HDL胆固醇、胰岛素分泌、血清甘油三酯、体重和体力活动之间的协方差，但不支持HDL是临床前冠心病中年男性主要“负性危险因素”这一理论。
