Jefferson-Myrna Brind Center of Integrative Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Stress Health. 2012 Dec;28(5):397-407. doi: 10.1002/smi.2470.
This study employed functional magnetic resonance imaging to evaluate changes in cerebral blood flow (CBF) associated with the Mindfulness-based Art Therapy (MBAT) programme and correlate such changes to stress and anxiety in women with breast cancer. Eighteen breast cancer patients were randomized to the MBAT or education control group. The patients received the diagnosis of breast cancer between 6 months and 3 years prior to enrollment and were not in active treatment. The age of participants ranged from 52 to 77 years. A voxel-based analysis was performed to assess differences at rest, during meditation and during a stress task. The anxiety sub-scale of the Symptoms Checklist-90-Revised was compared with changes in resting CBF before and after the programmes. Subjects in the MBAT arm demonstrated significant increases in CBF at rest and during meditation in multiple limbic regions, including the left insula, right amygdala, right hippocampus and bilateral caudate. Patients in the MBAT programme also had a significant correlation between increased CBF in the left caudate and decreased anxiety scores. In the MBAT group, responses to a stressful cue resulted in reduced activation of the posterior cingulate. The results demonstrate that the MBAT programme was associated with significant changes in CBF, which correlated with decreased anxiety over an 8-week period.
本研究采用功能磁共振成像评估了正念艺术治疗（MBAT）项目相关的脑血流（CBF）变化，并将这些变化与乳腺癌女性的应激和焦虑相关联。18 名乳腺癌患者被随机分配到 MBAT 或教育对照组。患者在入组前 6 个月至 3 年内被诊断出患有乳腺癌，且未处于积极治疗中。参与者的年龄在 52 至 77 岁之间。采用基于体素的分析方法评估静息、冥想和应激任务期间的差异。比较了症状清单 90 修订版的焦虑子量表与方案前后静息 CBF 的变化。MBAT 组在静息状态和冥想时多个边缘区域（包括左岛叶、右杏仁核、右海马体和双侧尾状核）的 CBF 均显著增加。MBAT 方案中的患者在左尾状核的 CBF 增加与焦虑评分降低之间也存在显著相关性。在 MBAT 组中，对应激线索的反应导致后扣带回的激活减少。结果表明，MBAT 方案与 CBF 的显著变化相关，这些变化与 8 周内焦虑的降低相关。
