National Research Council of Canada, Institute for Information Technology, 100 des Aboiteaux Street, Moncton, NB, E1A 7R1, Canada.
Future Oncol. 2012 Oct;8(10):1315-30. doi: 10.2217/fon.12.121.
The metabolism of tumors is remarkably different from the metabolism of corresponding normal cells and tissues. Metabolic alterations are initiated by oncogenes and are required for malignant transformation, allowing cancer cells to resist some cell death signals while producing energy and fulfilling their biosynthetic needs with limiting resources. The distinct metabolic phenotype of cancers provides an interesting avenue for treatment, potentially with minimal side effects. As many cancers show similar metabolic characteristics, drugs targeting the cancer metabolic phenotype are, perhaps optimistically, expected to be 'magic bullet' treatments. Over the last few years there have been a number of potential drugs developed to specifically target cancer metabolism. Several of these drugs are currently in clinical and preclinical trials. This review outlines examples of drugs developed for different targets of significance to cancer metabolism, with a focus on small molecule leads, chemical biology and clinical results for these drugs.
肿瘤的代谢与相应的正常细胞和组织的代谢显著不同。代谢改变是由癌基因引发的，是恶性转化所必需的，使癌细胞能够抵抗一些细胞死亡信号，同时利用有限的资源产生能量并满足其生物合成需求。癌症独特的代谢表型为治疗提供了一个有趣的途径，可能副作用最小。由于许多癌症表现出相似的代谢特征，因此靶向癌症代谢表型的药物有望成为“神奇子弹”治疗方法。在过去的几年中，已经开发出了许多针对特定癌症代谢靶点的潜在药物。其中一些药物目前正在进行临床前和临床试验。本文综述了为癌症代谢的不同重要靶点开发的药物示例，重点介绍了这些药物的小分子先导物、化学生物学和临床结果。
