设置 EMT 期间的 Snail2 速度。
Setting Snail2's pace during EMT.
机构信息
Molecular, Cellular and Developmental Biology Program, Ohio State University, and the OSU Comprehensive Cancer Center, Columbus, Ohio, USA.
出版信息
Nat Cell Biol. 2012 Nov;14(11):1122-3. doi: 10.1038/ncb2616.
DOI:10.1038/ncb2616
PMID:23131919
Abstract
Epithelial to mesenchymal transition (EMT) is a fundamental process in both development and cancer progression. The transcription factor Elf5 is now reported as an upstream regulator of the key EMT inducer Snail2, and is shown to regulate the earliest known rewiring events required for tumour cell invasiveness and metastasis.
摘要
上皮间质转化（EMT）是发育和癌症进展过程中的基本过程。转录因子 Elf5 现在被报道为关键 EMT 诱导因子 Snail2 的上游调节剂，并被证明调节肿瘤细胞侵袭和转移所需的最早已知重布线事件。
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