Gaytán Becerril A, Franco Muñoz P A, Rivera Hidalgo P, Gueda Baca S
Bol Med Hosp Infant Mex. 1978 Jan-Feb;35(1):1-12.
Seventeen infants under one year of age admitted to the Emergency Service of the General Hospital of the Medical Center La Raza during the year 1976 were included in this study with the diagnosis of salicylate poisoning. Determination of plasma salicylate by the ultrafiltrate method was practiced to all patients. A direct relationship between total plasmatic salicylate and its free fraction was found together with an inverse proportion between percentage of total free--salicylate and plasma pH and a lineal correlation between plasma free--salicylate and salicylate obtained in spinal fluid. It is concluded that determination of the free fraction of plasma salicylate is an easy diagnostic method for the better evaluation of salicylate acid poisoning in the infant.
1976年，拉扎医疗中心综合医院急诊科收治的17名1岁以下婴儿被纳入本研究，诊断为水杨酸盐中毒。对所有患者均采用超滤法测定血浆水杨酸盐。发现血浆总水杨酸盐与其游离部分之间存在直接关系，总游离水杨酸盐百分比与血浆pH值之间呈反比，血浆游离水杨酸盐与脑脊液中水杨酸盐之间呈线性相关。结论是，测定血浆水杨酸盐的游离部分是一种简单的诊断方法，有助于更好地评估婴儿水杨酸中毒情况。
