Petroff O A, Novotny E J, Ogino T, Avison M, Prichard J W
Department of Neurology, Yale University, New Haven, CT 06510.
J Neurochem. 1990 Apr;54(4):1188-95. doi: 10.1111/j.1471-4159.1990.tb01947.x.
In vivo 1H magnetic resonance spectroscopy was used to measure the cerebral ethanol concentration in the rabbit after both intraarterial and intragastric administration. There was good agreement between cerebral and blood ethanol concentrations at all times after administration by either route. Cerebral ethanol levels, measured using in vivo 1H spectroscopy, agreed well with those measured in perchloric acid extracts of brain, analyzed by both high-resolution 1H spectroscopy and gas chromatography. Ethanol may be useful as an indicator to measure cerebral blood flow by 1H spectroscopy and chemical shift-selective magnetic resonance imaging.
采用体内1H磁共振波谱法测量家兔经动脉内和胃内给药后的脑乙醇浓度。两种给药途径后，在所有时间点脑乙醇浓度与血乙醇浓度之间均具有良好的一致性。使用体内1H波谱法测得的脑乙醇水平与通过高分辨率1H波谱法和气相色谱法分析的脑高氯酸提取物中测得的水平高度一致。乙醇可用作通过1H波谱法和化学位移选择性磁共振成像测量脑血流量的指示剂。
