Chiu T M, Mendelson J H, Woods B T, Teoh S K, Levisohn L, Mello N K
Department of Neurology, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02178.
Magn Reson Med. 1994 Oct;32(4):511-6. doi: 10.1002/mrm.1910320414.
Alcohol tolerance was ascertained with in vivo proton magnetic resonance spectroscopy (MRS) in men who regularly consumed either large (10-20 drinks/week) or small (2-4 drinks/weeks) amounts of beverage alcohol. Brain ethanol concentrations were determined by MRS, and blood ethanol levels were measured by gas chromatography after controlled ethanol administration (0.8 g/kg). Brain-blood ethanol concentration ratios for heavy drinkers were significantly greater than ratios for occasional drinkers (P < 0.002). Inasmuch as ethanol tolerance covaries with the severity of dependence, MRS procedures may facilitate our understanding of alcohol tolerance and treatment of alcoholism.
通过体内质子磁共振波谱法（MRS）对定期大量（每周10 - 20杯）或少量（每周2 - 4杯）饮用酒精饮料的男性进行酒精耐受性测定。通过MRS测定脑乙醇浓度，在控制性给予乙醇（0.8 g/kg）后用气相色谱法测量血液乙醇水平。重度饮酒者的脑-血乙醇浓度比显著高于偶尔饮酒者（P < 0.002）。由于乙醇耐受性与依赖严重程度相关，MRS程序可能有助于我们理解酒精耐受性及酒精中毒的治疗。
