神经炎症和神经退行性疾病中血脑屏障的炎症事件：对临床疾病的影响。

Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease.

机构信息

Blood-Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.

出版信息

Epilepsia. 2012 Nov;53 Suppl 6(Suppl 6):45-52. doi: 10.1111/j.1528-1167.2012.03702.x.

DOI:10.1111/j.1528-1167.2012.03702.x

PMID:23134495

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4853914/

Abstract

Proper function of the neurovasculature is required for optimal brain function and preventing neuroinflammation and neurodegeneration. Within this review, we discuss alterations of the function of the blood-brain barrier in neurologic disorders such as multiple sclerosis, epilepsy, and Alzheimer's disease and address potential underlying mechanisms.

摘要

神经脉管系统的正常功能对于大脑的最佳功能和预防神经炎症和神经退行性变是必需的。在这篇综述中，我们讨论了神经紊乱（如多发性硬化症、癫痫和阿尔茨海默病）中血脑屏障功能的改变，并探讨了潜在的潜在机制。