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神经炎症和神经退行性疾病中血脑屏障的炎症事件：对临床疾病的影响。

Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease.

机构信息

Blood-Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.

出版信息

Epilepsia. 2012 Nov;53 Suppl 6(Suppl 6):45-52. doi: 10.1111/j.1528-1167.2012.03702.x.

DOI:10.1111/j.1528-1167.2012.03702.x
PMID:23134495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4853914/
Abstract

Proper function of the neurovasculature is required for optimal brain function and preventing neuroinflammation and neurodegeneration. Within this review, we discuss alterations of the function of the blood-brain barrier in neurologic disorders such as multiple sclerosis, epilepsy, and Alzheimer's disease and address potential underlying mechanisms.

摘要

神经脉管系统的正常功能对于大脑的最佳功能和预防神经炎症和神经退行性变是必需的。在这篇综述中，我们讨论了神经紊乱（如多发性硬化症、癫痫和阿尔茨海默病）中血脑屏障功能的改变，并探讨了潜在的潜在机制。

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Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease.神经炎症和神经退行性疾病中血脑屏障的炎症事件：对临床疾病的影响。
Epilepsia. 2012 Nov;53 Suppl 6(Suppl 6):45-52. doi: 10.1111/j.1528-1167.2012.03702.x.
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本文引用的文献

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Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis.血脑屏障功能障碍引起的脑病理和癫痫发生中的炎症信号转导。
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Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures.调制外周细胞毒性细胞和致痫模型中的癫痫发作。
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Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics.抗炎治疗在急性癫痫发作模型和儿科耐药性癫痫患者人群中的疗效。
PLoS One. 2011 Mar 28;6(3):e18200. doi: 10.1371/journal.pone.0018200.
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Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta.清道夫受体 CD36 对于淀粉样蛋白-β诱导的脑血管氧化应激和神经血管功能障碍是必不可少的。
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