Kim Su-Mi, Oh Sun-Ju, Hur Bang
Department of Pathology, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.
Korean J Pathol. 2012 Oct;46(5):429-35. doi: 10.4132/KoreanJPathol.2012.46.5.429. Epub 2012 Oct 25.
Recent reports have indicated that overexpression of mucin (MUC) 1 and/or MUC4 correlates with the occurrence and progression of extra-hepatobiliary malignancy. In this study, we investigated the expression of MUC1 and MUC4 and their prognostic significance in gallbladder adenocarcinoma.
We examined 54 surgical gallbladder adenocarcinoma samples by immunohistochemistry for MUC1 and MUC4 expression. Staining was evaluated as a sum score of extent and intensity, dividing the samples into low and high expression groups.
The low expression group for both MUC1 and MUC4 was 10 samples (18.5%), and the high expression group was 44 samples (81.5%). High MUC1 expression was significantly correlated with more differentiated tumors (p=0.033), whereas high expression of MUC4 correlated with negative nodal status (p=0.012). Other pathological features were not correlated with MUC expression. Multivariate cox regression analysis showed that neither MUC1 nor MUC4 expression correlated with survival.
Although there were some correlations found, a prognostic role for either MUC1 or MUC4 expression in gallbladder carcinoma was not identified in this study. Further investigation is required.
最近的报告表明，粘蛋白（MUC）1和/或MUC4的过表达与肝外恶性肿瘤的发生和进展相关。在本研究中，我们调查了MUC1和MUC4在胆囊腺癌中的表达及其预后意义。
我们通过免疫组织化学检查了54例手术切除的胆囊腺癌样本中MUC1和MUC4的表达情况。染色结果根据范围和强度的总和进行评估，将样本分为低表达组和高表达组。
MUC1和MUC4均为低表达的样本有10例（18.5%），高表达的样本有44例（81.5%）。MUC1高表达与肿瘤分化程度更高显著相关（p=0.033），而MUC4高表达与阴性淋巴结状态相关（p=0.012）。其他病理特征与MUC表达无关。多因素Cox回归分析显示，MUC1和MUC4的表达均与生存无关。
尽管发现了一些相关性，但本研究未确定MUC1或MUC4表达在胆囊癌中的预后作用。需要进一步研究。
