Kim Yo Na, Choi Ji Eun, Bae Jun Sang, Jang Kyu Yun, Chung Myoung Ja, Moon Woo Sung, Kang Myoung Jae, Lee Dong Geun, Park Ho Sung
Department of Pathology, Chonbuk National University Medical School, Jeonju, Korea.
Korean J Pathol. 2012 Oct;46(5):454-62. doi: 10.4132/KoreanJPathol.2012.46.5.454. Epub 2012 Oct 25.
Cortactin and focal adhesion kinase (FAK) are two important components among actin cross-linking proteins that play a central role in cell migration.
The aims of this study were to evaluate the expression of cortactin and FAK in normal colorectal mucosa and colorectal adenocarcinoma (CRC) using tissue microarray of 2 mm cores to correlate their expression with other clinicopathological factors and, investigate their prognostic significance.
Twenty (9%) and 24 cases (11%) of normal colorectal mucosa were immunoreactive for cortactin and FAK. In addition, 184 (84%) and 133 cases (61%) of CRCs were immunoreactive for cortactin and FAK, respectively. Cortactin expression was associated with histologic differentiation and FAK expression. Cortactin, but not FAK expression was also correlated with poor overall and relapse-free survival and served well as an independent prognostic factor for poor survival.
Cortactin expression, in association with FAK expression, may plays an important role in tumor progression. Furthermore, it may also be a satisfactory biomarker to predict tumor progression and survival in CRC patients.
皮层肌动蛋白（cortactin）和粘着斑激酶（FAK）是肌动蛋白交联蛋白中的两个重要组成部分，在细胞迁移中起核心作用。
本研究旨在使用2毫米芯组织微阵列评估正常结直肠黏膜和结直肠癌（CRC）中皮层肌动蛋白和粘着斑激酶的表达，将它们的表达与其他临床病理因素相关联，并研究它们的预后意义。
20例（9%）正常结直肠黏膜对皮层肌动蛋白呈免疫反应，24例（11%）对粘着斑激酶呈免疫反应。此外，184例（84%）和133例（61%）的结直肠癌分别对皮层肌动蛋白和粘着斑激酶呈免疫反应。皮层肌动蛋白表达与组织学分化和粘着斑激酶表达相关。皮层肌动蛋白而非粘着斑激酶的表达也与总体生存率和无复发生存率低相关，并且是生存率低的一个良好独立预后因素。
皮层肌动蛋白表达与粘着斑激酶表达相关，可能在肿瘤进展中起重要作用。此外，它也可能是预测CRC患者肿瘤进展和生存的一个令人满意的生物标志物。
