Wigle D T, Semenciw R M, Wilkins K, Riedel D, Ritter L, Morrison H I, Mao Y
Laboratory Centre for Disease Control, Ottawa, ON, Canada.
J Natl Cancer Inst. 1990 Apr 4;82(7):575-82. doi: 10.1093/jnci/82.7.575.
A cohort study of the mortality experience (1971-1985) of male Saskatchewan farmers has been conducted. This study involved linkage of records of the almost 70,000 male farmers identified on the 1971 Census of Agriculture and the corresponding Census of Population to mortality records. Pesticide exposure indices for individual farm operators for the year 1970 were derived from the 1971 Census of Agriculture records. Although the cohort as a whole had no excess mortality for any specific causes of death, including non-Hodgkin's lymphoma, significant dose-response relationships were noted between risk of non-Hodgkin's lymphoma and acres sprayed in 1970 with herbicides, as well as with dollars spent on fuel and oil for farm purposes in 1970. Using Poisson regression modeling, we found that relative risks for the highest level of herbicide use (greater than or equal to 250 acres sprayed) and fuel purchased in 1970 (greater than or equal to $900) on farms less than 1,000 acres total area were 2.2 (95% confidence interval = 1.0-4.6) and 2.3 (95% confidence interval = 1.1-4.7), respectively.
对萨斯喀彻温省男性农民的死亡经历（1971 - 1985年）进行了一项队列研究。该研究涉及将1971年农业普查中确定的近70000名男性农民的记录与相应的人口普查记录与死亡记录相联系。1970年个体农场经营者的农药暴露指数来自1971年农业普查记录。尽管该队列总体上在任何特定死因方面都没有超额死亡率，包括非霍奇金淋巴瘤，但在非霍奇金淋巴瘤风险与1970年用除草剂喷洒的英亩数以及1970年用于农场目的的燃料和机油支出之间发现了显著的剂量反应关系。使用泊松回归模型，我们发现，对于总面积小于1000英亩的农场，1970年除草剂使用量最高水平（大于或等于250英亩喷洒）和燃料购买量最高水平（大于或等于900美元）的相对风险分别为2.2（95%置信区间 = 1.0 - 4.6）和2.3（95%置信区间 = 1.1 - 4.7）。
