Department of Infectious Diseases, Singapore General Hospital, Singapore.
J Clin Virol. 2013 Jan;56(1):37-40. doi: 10.1016/j.jcv.2012.10.005. Epub 2012 Nov 6.
Human parainfluenza virus (HPIV) infection as an aetiology of acute viral myocarditis is rare, with only few cases reported in the literature to date. Here we report a case of fulminant HPIV-2 myocarditis in a 47 year-old man with viraemia who was successfully treated with intravenous ribavirin and intravenous immunoglobulin (IVIG). There are currently no recommendations on the treatment of HPIV myocarditis. We are, to our knowledge, the first to report a patient with a documented HPIV-2 viraemia that subsequently cleared after the initiation of antiviral therapy. Although it is difficult to definitively attribute the patient's clinical improvement to ribavirin or IVIG alone, our case does suggest that clinicians may wish to consider initiating ribavirin and IVIG in patients with HPIV myocarditis and persistent viraemia not responding to supportive measures alone.
人类副流感病毒（HPIV）感染作为急性病毒性心肌炎的病因很少见，迄今为止，文献中仅报道了少数几例。在此，我们报告了一例 47 岁男性暴发性 HPIV-2 心肌炎的病例，该患者伴有病毒血症，经静脉用利巴韦林和静脉注射免疫球蛋白（IVIG）治疗后成功治愈。目前，尚无关于 HPIV 心肌炎治疗的建议。据我们所知，我们是首例报告明确的 HPIV-2 病毒血症患者，在开始抗病毒治疗后病毒血症得到清除。虽然很难确定患者的临床改善是否仅归因于利巴韦林或 IVIG，但我们的病例确实表明，对于单独支持治疗无效且持续存在病毒血症的 HPIV 心肌炎患者，临床医生可能希望考虑开始使用利巴韦林和 IVIG。
