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奥氮平导致尿失禁:一例报告。

Olanzapine as a cause of urinary incontinence: a case report.

作者信息

Dada Mobolaji Usman, Oluwole Lateef Olutoyin, Adegun Patrick T, Tareo Peter O

机构信息

Department of Psychiatry, University Teaching Hospital, Ado-Ekiti, Ekiti State, Nigeria.

出版信息

Iran J Psychiatry. 2012 Summer;7(3):146-8.

Abstract

Olanzapine, an atypical antipsychotic, is one of the most commonly used antipsychotics. Though olanzapine is commonly associated with endocrine side effects, it is generally well tolerated by most patients and is rarely associated with urinary incontinence. This report highlights the case of a 23 -year old male patient with schizophrenia who developed severe urinary incontinence following the use of olanzapine. No medications were given to relieve the incontinence contrary to some other studies where ephedrine was used. Olanzapine was changed to trifluoperazine, and the patient's condition improved within two days. Urinary incontinence, though uncommon, is an embarrassing side effect of olanzapine which could negatively affect drug compliance. As such, clinicians should enquire about it in order to improve the patient's health.

摘要

奥氮平是一种非典型抗精神病药物,是最常用的抗精神病药物之一。虽然奥氮平通常与内分泌副作用有关,但大多数患者对其耐受性良好,很少与尿失禁相关。本报告重点介绍了一名23岁的男性精神分裂症患者,在使用奥氮平后出现了严重的尿失禁。与其他一些使用麻黄碱的研究不同,该患者未给予任何药物来缓解尿失禁。将奥氮平换成三氟拉嗪后,患者的病情在两天内得到改善。尿失禁虽然不常见,但却是奥氮平令人尴尬的副作用,可能会对药物依从性产生负面影响。因此,临床医生应该对此进行询问,以改善患者的健康状况。

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